Drug interactions
Bedaquiline + Goserelin
Severity: Major
Bedaquiline and Goserelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline has a labeled QT prolongation warning, and goserelin may add a smaller effect. Together they may raise the risk of serious ventricular arrhythmia, especially in patients on other QT-prolonging TB drugs.
What this interaction means in plain words
Bedaquiline and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and repeat it during treatment, correcting potassium, calcium and magnesium. Consider an alternative to goserelin or interrupt bedaquiline if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Goserelin?
MediHelp rates the interaction as major. Bedaquiline and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline has a labeled QT prolongation warning, and goserelin may add a smaller effect. Together they may raise the risk of serious ventricular arrhythmia, especially in patients on other QT-prolonging TB drugs.
How serious is the interaction between Bedaquiline and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during treatment, correcting potassium, calcium and magnesium. Consider an alternative to goserelin or interrupt bedaquiline if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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