Drug interactions
Dofetilide + Goserelin
Severity: Major
Dofetilide and Goserelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide causes dose-dependent QT prolongation and torsades de pointes, and goserelin may add to this through androgen deprivation. The combination increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Dofetilide and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation: dofetilide blocks IKr and androgen deprivation may prolong repolarization.
What to do
Avoid the combination where possible. If both are required, monitor the ECG and QTc closely, keep electrolytes normal, and adjust the dofetilide dose according to the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Goserelin?
MediHelp rates the interaction as major. Dofetilide and Goserelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide causes dose-dependent QT prolongation and torsades de pointes, and goserelin may add to this through androgen deprivation. The combination increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Dofetilide and Goserelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor the ECG and QTc closely, keep electrolytes normal, and adjust the dofetilide dose according to the QTc.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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