Drug interactions
Artemether / lumefantrine + Loratadine
Severity: Minor
Artemether / lumefantrine and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, while artemether may induce CYP3A4, so loratadine and its active metabolite could change in either direction. The net effect on loratadine is unclear and likely small.
What this interaction means in plain words
Artemether / lumefantrine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on loratadine metabolism: CYP2D6 inhibition by lumefantrine and CYP3A4 induction by artemether.
What to do
No dose change is usually needed; monitor for sedation or reduced antihistamine effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Artemether / lumefantrine with Loratadine?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine inhibits CYP2D6, while artemether may induce CYP3A4, so loratadine and its active metabolite could change in either direction. The net effect on loratadine is unclear and likely small.
How serious is the interaction between Artemether / lumefantrine and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for sedation or reduced antihistamine effect.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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