Drug interactions
Artemether / lumefantrine + Oxycodone
Severity: Minor
Artemether / lumefantrine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine inhibits CYP2D6, but oxycodone is mainly cleared by CYP3A4, and the clinical effect of CYP2D6 inhibition on oxycodone is small. The interaction is largely theoretical and likely of limited importance.
What this interaction means in plain words
Artemether / lumefantrine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2D6 inhibition by lumefantrine altering oxycodone metabolism; clinical significance is not established.
What to do
No dose change is generally needed; monitor analgesic response and sedation during the antimalarial course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Oxycodone?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine inhibits CYP2D6, but oxycodone is mainly cleared by CYP3A4, and the clinical effect of CYP2D6 inhibition on oxycodone is small. The interaction is largely theoretical and likely of limited importance.
How serious is the interaction between Artemether / lumefantrine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor analgesic response and sedation during the antimalarial course.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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