Drug interactions
Artemether / lumefantrine + Ranolazine
Severity: Moderate
Artemether / lumefantrine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether and lumefantrine can induce CYP3A4, potentially lowering ranolazine levels and reducing antianginal effect. Both agents are also associated with QT prolongation, adding concern.
What this interaction means in plain words
Artemether / lumefantrine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible weak CYP3A4 induction lowers ranolazine exposure, with additive QT effects.
What to do
Monitor angina control and ECG QTc during the short antimalarial course. Consider a non-QT-prolonging alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Ranolazine?
MediHelp rates the interaction as moderate. Artemether / lumefantrine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artemether and lumefantrine can induce CYP3A4, potentially lowering ranolazine levels and reducing antianginal effect. Both agents are also associated with QT prolongation, adding concern.
How serious is the interaction between Artemether / lumefantrine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor angina control and ECG QTc during the short antimalarial course. Consider a non-QT-prolonging alternative if feasible.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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