Drug interactions
Artemether / lumefantrine + Temsirolimus
Severity: Minor
Artemether / lumefantrine and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether may induce CYP3A4 and slightly lower temsirolimus and sirolimus exposure, whereas lumefantrine is a CYP2D6 inhibitor. With a short antimalarial course, the effect is likely small.
What this interaction means in plain words
Artemether / lumefantrine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Artemether induces CYP3A4, increasing metabolism of temsirolimus and its active metabolite sirolimus.
What to do
No empirical dose change is usually needed; monitor clinical response during the short malaria treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Artemether / lumefantrine with Temsirolimus?
MediHelp rates the interaction as minor. Artemether / lumefantrine and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether may induce CYP3A4 and slightly lower temsirolimus and sirolimus exposure, whereas lumefantrine is a CYP2D6 inhibitor. With a short antimalarial course, the effect is likely small.
How serious is the interaction between Artemether / lumefantrine and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is usually needed; monitor clinical response during the short malaria treatment course.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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