Drug interactions
Artesunate + Diflunisal
Severity: Minor
Artesunate and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal inhibits UGT enzymes, which are responsible for clearing dihydroartemisinin, the active metabolite of artesunate. Exposure to the metabolite may rise, though the clinical impact is uncertain.
What this interaction means in plain words
Artesunate and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Artesunate belongs to Anti Parasitic; Diflunisal belongs to Musculoskeletal.
Why it happens
Inhibition of UGT-mediated glucuronidation of dihydroartemisinin.
What to do
No dose change is usually needed; monitor for artesunate adverse effects during short-course use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
Frequently asked questions
Can I take Artesunate with Diflunisal?
MediHelp rates the interaction as minor. Artesunate and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diflunisal inhibits UGT enzymes, which are responsible for clearing dihydroartemisinin, the active metabolite of artesunate. Exposure to the metabolite may rise, though the clinical impact is uncertain.
How serious is the interaction between Artesunate and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for artesunate adverse effects during short-course use.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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