Drug interactions
Artesunate + Regorafenib
Severity: Moderate
Artesunate and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may raise exposure to dihydroartemisinin, the active metabolite of artesunate, because it inhibits UGT1A9 which clears this metabolite. Higher levels could increase artesunate-related adverse effects such as hematologic toxicity and liver enzyme elevations.
What this interaction means in plain words
Artesunate and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibits UGT-mediated glucuronidation of dihydroartemisinin, reducing its clearance.
What to do
Monitor blood counts and liver function when artesunate is given to a patient on regorafenib. Watch for signs of increased artesunate toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Eltrombopag Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
Frequently asked questions
Can I take Artesunate with Regorafenib?
MediHelp rates the interaction as moderate. Artesunate and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may raise exposure to dihydroartemisinin, the active metabolite of artesunate, because it inhibits UGT1A9 which clears this metabolite. Higher levels could increase artesunate-related adverse effects such as hematologic toxicity and liver enzyme elevations.
How serious is the interaction between Artesunate and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver function when artesunate is given to a patient on regorafenib. Watch for signs of increased artesunate toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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