Drug interactions
Asenapine + Avapritinib
Severity: Moderate
Asenapine and Avapritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence, and asenapine is sedating. Together they may increase drowsiness and cognitive impairment.
What this interaction means in plain words
Asenapine and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Avapritinib belongs to Oncology.
Why it happens
Additive CNS effects; no specific pharmacokinetic mechanism established.
What to do
Monitor for sedation and cognitive changes and counsel against driving until the response is known. Adjust doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Asenapine with Avapritinib?
MediHelp rates the interaction as moderate. Asenapine and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence, and asenapine is sedating. Together they may increase drowsiness and cognitive impairment.
How serious is the interaction between Asenapine and Avapritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and counsel against driving until the response is known. Adjust doses if impairment occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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