Drug interactions
Asenapine + Carbamazepine
Severity: Moderate
Asenapine and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes and may lower asenapine concentrations, reducing antipsychotic effect. The reduction is modest in available data, but loss of efficacy is possible.
What this interaction means in plain words
Asenapine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP and UGT enzymes involved in asenapine metabolism.
What to do
Monitor psychiatric response and consider an asenapine dose increase if efficacy declines; reassess if carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Asenapine with Carbamazepine?
MediHelp rates the interaction as moderate. Asenapine and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes and may lower asenapine concentrations, reducing antipsychotic effect. The reduction is modest in available data, but loss of efficacy is possible.
How serious is the interaction between Asenapine and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and consider an asenapine dose increase if efficacy declines; reassess if carbamazepine is stopped.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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