Drug interactions
Asenapine + Clevidipine
Severity: Moderate
Asenapine and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension through alpha-1 blockade, and clevidipine is a potent intravenous vasodilator. Together they may cause greater blood pressure reductions than expected.
What this interaction means in plain words
Asenapine and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Clevidipine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects: alpha-1 adrenergic blockade plus calcium channel blockade vasodilation.
What to do
Monitor blood pressure closely and titrate clevidipine cautiously by response. Watch for orthostatic symptoms after transition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Asenapine with Clevidipine?
MediHelp rates the interaction as moderate. Asenapine and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension through alpha-1 blockade, and clevidipine is a potent intravenous vasodilator. Together they may cause greater blood pressure reductions than expected.
How serious is the interaction between Asenapine and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and titrate clevidipine cautiously by response. Watch for orthostatic symptoms after transition.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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