Drug interactions
Asenapine + Clomipramine
Severity: Moderate
Asenapine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause sedation, and asenapine is a weak CYP2D6 inhibitor that may modestly increase clomipramine exposure. The combination may increase arrhythmia and sedation risk.
What this interaction means in plain words
Asenapine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression, plus weak CYP2D6 inhibition.
What to do
Obtain a baseline ECG and electrolytes and monitor for sedation and tricyclic toxicity. Reduce the clomipramine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Clomipramine?
MediHelp rates the interaction as moderate. Asenapine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause sedation, and asenapine is a weak CYP2D6 inhibitor that may modestly increase clomipramine exposure. The combination may increase arrhythmia and sedation risk.
How serious is the interaction between Asenapine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and monitor for sedation and tricyclic toxicity. Reduce the clomipramine dose if adverse effects appear.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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