Drug interactions
Asenapine + Daridorexant
Severity: Moderate
Asenapine and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, and combining them may increase somnolence and impair psychomotor performance and next-day alertness.
What this interaction means in plain words
Asenapine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Daridorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from antipsychotic sedation and orexin receptor antagonism.
What to do
Use the lowest effective daridorexant dose and counsel about next-day impairment and driving. Reassess the need for both agents if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Asenapine with Daridorexant?
MediHelp rates the interaction as moderate. Asenapine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, and combining them may increase somnolence and impair psychomotor performance and next-day alertness.
How serious is the interaction between Asenapine and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel about next-day impairment and driving. Reassess the need for both agents if excessive sedation occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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