Drug interactions
Asenapine + Desflurane
Severity: Moderate
Asenapine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine and the volatile anesthetic desflurane may each lengthen the QTc interval. Their combination during surgery increases the chance of arrhythmia, especially with other risk factors.
What this interaction means in plain words
Asenapine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on ventricular repolarization.
What to do
Review baseline ECG and correct potassium and magnesium before anesthesia. Monitor ECG perioperatively and inform the anesthetist of asenapine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Desflurane
Frequently asked questions
Can I take Asenapine with Desflurane?
MediHelp rates the interaction as moderate. Asenapine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine and the volatile anesthetic desflurane may each lengthen the QTc interval. Their combination during surgery increases the chance of arrhythmia, especially with other risk factors.
How serious is the interaction between Asenapine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and correct potassium and magnesium before anesthesia. Monitor ECG perioperatively and inform the anesthetist of asenapine use.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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