Drug interactions
Azelastine + Dexchlorpheniramine
Severity: Moderate
Azelastine and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are H1 antihistamines, and dexchlorpheniramine is sedating and anticholinergic. Combined use duplicates therapy and increases drowsiness and anticholinergic effects.
What this interaction means in plain words
Azelastine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Duplicate H1 antagonism producing additive sedation and anticholinergic effects.
What to do
Avoid concurrent use and choose one antihistamine. If unavoidable, monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine and Dexchlorpheniramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Azelastine
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Azelastine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Azelastine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are H1 antihistamines, and dexchlorpheniramine is sedating and anticholinergic. Combined use duplicates therapy and increases drowsiness and anticholinergic effects.
How serious is the interaction between Azelastine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose one antihistamine. If unavoidable, monitor for sedation and anticholinergic effects.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
