Drug interactions
Asenapine + Eliglustat
Severity: Major
Asenapine and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QTc interval, so concurrent use may increase the risk of arrhythmias. Eliglustat is itself linked to conduction and QT effects at high exposures.
What this interaction means in plain words
Asenapine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Additive prolongation of the QT interval; the pharmacodynamic effects are additive.
What to do
Avoid the pairing if an alternative is available. If both are required, obtain a baseline and follow-up ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Asenapine with Eliglustat?
MediHelp rates the interaction as major. Asenapine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have the potential to prolong the QTc interval, so concurrent use may increase the risk of arrhythmias. Eliglustat is itself linked to conduction and QT effects at high exposures.
How serious is the interaction between Asenapine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the pairing if an alternative is available. If both are required, obtain a baseline and follow-up ECG and correct electrolyte abnormalities.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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