Drug interactions
Asenapine + Entacapone
Severity: Moderate
Asenapine and Entacapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone enhances dopaminergic therapy and can cause dizziness, somnolence and dyskinesia, while asenapine blocks dopamine receptors. The drugs have opposing dopaminergic effects, and asenapine may worsen parkinsonism, while both can add to sedation.
What this interaction means in plain words
Asenapine and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Entacapone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors, with additive CNS depressant effects.
What to do
Monitor motor symptoms and psychiatric status, and counsel about drowsiness. In Parkinson's disease, choose an antipsychotic with minimal D2 blockade such as quetiapine or clozapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Asenapine with Entacapone?
MediHelp rates the interaction as moderate. Asenapine and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entacapone enhances dopaminergic therapy and can cause dizziness, somnolence and dyskinesia, while asenapine blocks dopamine receptors. The drugs have opposing dopaminergic effects, and asenapine may worsen parkinsonism, while both can add to sedation.
How serious is the interaction between Asenapine and Entacapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and psychiatric status, and counsel about drowsiness. In Parkinson's disease, choose an antipsychotic with minimal D2 blockade such as quetiapine or clozapine.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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