Drug interactions
Asenapine + Esmolol
Severity: Moderate
Asenapine and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks alpha-1 receptors and can cause orthostatic hypotension, which may add to the blood pressure lowering of esmolol. Hypotension is more likely in volume-depleted patients or at higher doses.
What this interaction means in plain words
Asenapine and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Esmolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from beta-blockade and alpha-1 adrenergic antagonism.
What to do
Monitor blood pressure during esmolol infusion in patients receiving asenapine and titrate esmolol conservatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Esmolol?
MediHelp rates the interaction as moderate. Asenapine and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks alpha-1 receptors and can cause orthostatic hypotension, which may add to the blood pressure lowering of esmolol. Hypotension is more likely in volume-depleted patients or at higher doses.
How serious is the interaction between Asenapine and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during esmolol infusion in patients receiving asenapine and titrate esmolol conservatively.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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