Drug interactions
Asenapine + Flibanserin
Severity: Moderate
Asenapine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and can lower blood pressure, so combined use may increase drowsiness, dizziness and syncope. Serotonergic and neuroleptic malignant syndrome-type effects are theoretically possible with combined serotonergic and dopamine-blocking activity.
What this interaction means in plain words
Asenapine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression and hypotension, with overlapping serotonergic and dopaminergic receptor effects.
What to do
Monitor for excessive sedation, hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Advise against driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Flibanserin?
MediHelp rates the interaction as moderate. Asenapine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and can lower blood pressure, so combined use may increase drowsiness, dizziness and syncope. Serotonergic and neuroleptic malignant syndrome-type effects are theoretically possible with combined serotonergic and dopamine-blocking activity.
How serious is the interaction between Asenapine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Advise against driving and alcohol until the response is known.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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