Drug interactions
Asenapine + Haloperidol
Severity: Moderate
Asenapine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antipsychotics that can prolong the QT interval and cause sedation, so combining them adds to the risk of arrhythmia and drowsiness. Asenapine is a weak CYP2D6 inhibitor and may modestly raise haloperidol exposure, although this effect is of limited importance.
What this interaction means in plain words
Asenapine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QTc prolongation and CNS depression, with mild CYP2D6 inhibition by asenapine reducing haloperidol clearance.
What to do
Avoid routine antipsychotic polypharmacy where possible; if used together, obtain a baseline ECG and monitor QTc and electrolytes. Reduce the doses if excess sedation or QT lengthening occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Haloperidol?
MediHelp rates the interaction as moderate. Asenapine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antipsychotics that can prolong the QT interval and cause sedation, so combining them adds to the risk of arrhythmia and drowsiness. Asenapine is a weak CYP2D6 inhibitor and may modestly raise haloperidol exposure, although this effect is of limited importance.
How serious is the interaction between Asenapine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine antipsychotic polypharmacy where possible; if used together, obtain a baseline ECG and monitor QTc and electrolytes. Reduce the doses if excess sedation or QT lengthening occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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