Drug interactions
Asenapine + Imidapril
Severity: Moderate
Asenapine and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-1 blocking activity that can cause orthostatic hypotension, and ACE inhibitors such as imidapril lower blood pressure. Together they may produce additive hypotension, particularly after the first doses or dose increases.
What this interaction means in plain words
Asenapine and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Imidapril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when either drug is started or titrated. Advise patients to rise slowly, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Asenapine with Imidapril?
MediHelp rates the interaction as moderate. Asenapine and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has alpha-1 blocking activity that can cause orthostatic hypotension, and ACE inhibitors such as imidapril lower blood pressure. Together they may produce additive hypotension, particularly after the first doses or dose increases.
How serious is the interaction between Asenapine and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when either drug is started or titrated. Advise patients to rise slowly, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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