Drug interactions
Asenapine + Insulin glargine
Severity: Moderate
Asenapine and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can impair glucose tolerance and raise blood glucose, which may reduce the effectiveness of insulin glargine. Insulin requirements may rise.
What this interaction means in plain words
Asenapine and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Insulin glargine belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose insulin action; the exact mechanism is not fully established.
What to do
Check glucose more often after starting or changing asenapine. Titrate insulin glargine to the measured values.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Insulin glargine
Frequently asked questions
Can I take Asenapine with Insulin glargine?
MediHelp rates the interaction as moderate. Asenapine and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can impair glucose tolerance and raise blood glucose, which may reduce the effectiveness of insulin glargine. Insulin requirements may rise.
How serious is the interaction between Asenapine and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose more often after starting or changing asenapine. Titrate insulin glargine to the measured values.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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