Drug interactions
Asenapine + Itraconazole
Severity: Minor
Asenapine and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval, and itraconazole may add to the cardiac risk. Asenapine is metabolized mainly by UGT1A4 and CYP1A2, so a significant pharmacokinetic interaction is not expected.
What this interaction means in plain words
Asenapine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Possible additive effects on QT interval; no major metabolic interaction.
What to do
Consider a baseline ECG in patients with cardiac risk factors and correct electrolyte disturbances.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Itraconazole?
MediHelp rates the interaction as minor. Asenapine and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine can prolong the QT interval, and itraconazole may add to the cardiac risk. Asenapine is metabolized mainly by UGT1A4 and CYP1A2, so a significant pharmacokinetic interaction is not expected.
How serious is the interaction between Asenapine and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG in patients with cardiac risk factors and correct electrolyte disturbances.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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