Drug interactions
Asenapine + Labetalol
Severity: Moderate
Asenapine and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. With labetalol, which also blocks alpha-1 and beta receptors, hypotension and syncope may be more likely.
What this interaction means in plain words
Asenapine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Labetalol belongs to Cardiovascular.
Why it happens
Additive alpha-1 adrenergic blockade and antihypertensive effect.
What to do
Monitor orthostatic blood pressure when starting or increasing either drug and consider a lower labetalol dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Labetalol?
MediHelp rates the interaction as moderate. Asenapine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. With labetalol, which also blocks alpha-1 and beta receptors, hypotension and syncope may be more likely.
How serious is the interaction between Asenapine and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or increasing either drug and consider a lower labetalol dose if symptomatic.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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