Drug interactions
Chlorothiazide + Liraglutide
Severity: Moderate
Chlorothiazide and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can reduce insulin sensitivity and raise blood glucose. This may offset the glucose-lowering effect of liraglutide and worsen glycemic control.
What this interaction means in plain words
Chlorothiazide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazides cause hypokalemia and impaired insulin sensitivity and glucose tolerance.
What to do
Monitor blood glucose when starting, stopping or increasing the thiazide dose, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Liraglutide?
MediHelp rates the interaction as moderate. Chlorothiazide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can reduce insulin sensitivity and raise blood glucose. This may offset the glucose-lowering effect of liraglutide and worsen glycemic control.
How serious is the interaction between Chlorothiazide and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or increasing the thiazide dose, and adjust antidiabetic therapy if needed.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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