Drug interactions
Asenapine + Mefloquine
Severity: Major
Asenapine and Mefloquine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QTc interval, so concurrent use may increase the risk of torsades de pointes. The risk is higher in patients with bradycardia, electrolyte disturbances or congenital long QT.
What this interaction means in plain words
Asenapine and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if an alternative antimalarial exists. Otherwise obtain an ECG at baseline and during treatment and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Mefloquine?
MediHelp rates the interaction as major. Asenapine and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs may prolong the QTc interval, so concurrent use may increase the risk of torsades de pointes. The risk is higher in patients with bradycardia, electrolyte disturbances or congenital long QT.
How serious is the interaction between Asenapine and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antimalarial exists. Otherwise obtain an ECG at baseline and during treatment and correct potassium and magnesium.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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