Drug interactions
Asenapine + Meperidine
Severity: Moderate
Asenapine and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine causes sedation and orthostatic hypotension that may be worsened by meperidine. Meperidine's serotonergic activity combined with asenapine's receptor effects carries a small theoretical risk of serotonin toxicity.
What this interaction means in plain words
Asenapine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotension, with possible additive serotonergic effects.
What to do
Start with lower doses, monitor for oversedation and orthostasis, and watch for features of serotonin toxicity. Advise patients to rise slowly from sitting or lying.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Meperidine?
MediHelp rates the interaction as moderate. Asenapine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine causes sedation and orthostatic hypotension that may be worsened by meperidine. Meperidine's serotonergic activity combined with asenapine's receptor effects carries a small theoretical risk of serotonin toxicity.
How serious is the interaction between Asenapine and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses, monitor for oversedation and orthostasis, and watch for features of serotonin toxicity. Advise patients to rise slowly from sitting or lying.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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