Drug interactions
Asenapine + Metoprolol
Severity: Moderate
Asenapine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a weak CYP2D6 inhibitor and may modestly raise metoprolol levels. Asenapine can also cause orthostatic hypotension, adding to metoprolol blood pressure lowering.
What this interaction means in plain words
Asenapine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Weak CYP2D6 inhibition by asenapine plus additive hypotensive effects from alpha-adrenergic blockade and beta-blockade.
What to do
Monitor blood pressure, heart rate and orthostatic symptoms when combining, and lower the metoprolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Metoprolol?
MediHelp rates the interaction as moderate. Asenapine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is a weak CYP2D6 inhibitor and may modestly raise metoprolol levels. Asenapine can also cause orthostatic hypotension, adding to metoprolol blood pressure lowering.
How serious is the interaction between Asenapine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and orthostatic symptoms when combining, and lower the metoprolol dose if bradycardia or hypotension develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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