Drug interactions
Asenapine + Osimertinib
Severity: Moderate
Asenapine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine and osimertinib each have the potential to lengthen the QTc interval. Used together they may produce additive prolongation and increase the chance of ventricular arrhythmia, particularly in patients with electrolyte abnormalities.
What this interaction means in plain words
Asenapine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization through pharmacodynamic synergy.
What to do
Perform periodic ECG monitoring and check serum potassium and magnesium, correcting abnormalities. Stop or change therapy if QTc becomes markedly prolonged or symptoms of arrhythmia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asenapine and Osimertinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Asenapine with Osimertinib?
MediHelp rates the interaction as moderate. Asenapine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine and osimertinib each have the potential to lengthen the QTc interval. Used together they may produce additive prolongation and increase the chance of ventricular arrhythmia, particularly in patients with electrolyte abnormalities.
How serious is the interaction between Asenapine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and check serum potassium and magnesium, correcting abnormalities. Stop or change therapy if QTc becomes markedly prolonged or symptoms of arrhythmia appear.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
