Drug interactions
Asenapine + Temazepam
Severity: Moderate
Asenapine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines combined with antipsychotics produce additive sedation and psychomotor impairment, and can raise the risk of falls and respiratory depression. Orthostatic hypotension and syncope may also be more likely.
What this interaction means in plain words
Asenapine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation by temazepam and sedative antihistaminic and antiadrenergic effects of asenapine.
What to do
Use the lowest effective doses for the shortest duration and monitor sedation, blood pressure and respiratory status. Take particular care in older patients and those with respiratory disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Asenapine with Temazepam?
MediHelp rates the interaction as moderate. Asenapine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines combined with antipsychotics produce additive sedation and psychomotor impairment, and can raise the risk of falls and respiratory depression. Orthostatic hypotension and syncope may also be more likely.
How serious is the interaction between Asenapine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor sedation, blood pressure and respiratory status. Take particular care in older patients and those with respiratory disease.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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