Drug interactions
Asenapine + Ziconotide
Severity: Moderate
Asenapine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, given intrathecally, can cause somnolence, dizziness, confusion and other neuropsychiatric effects, and asenapine may add to the sedation. Ziconotide also carries a warning for psychiatric symptoms and cognitive impairment, which warrants attention in patients on antipsychotics.
What this interaction means in plain words
Asenapine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; ziconotide blocks N-type calcium channels while asenapine has sedating receptor actions.
What to do
Monitor for oversedation, confusion and mood or psychotic changes, particularly during ziconotide titration. Reduce or stop ziconotide if cognitive or psychiatric deterioration occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Asenapine with Ziconotide?
MediHelp rates the interaction as moderate. Asenapine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide, given intrathecally, can cause somnolence, dizziness, confusion and other neuropsychiatric effects, and asenapine may add to the sedation. Ziconotide also carries a warning for psychiatric symptoms and cognitive impairment, which warrants attention in patients on antipsychotics.
How serious is the interaction between Asenapine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and mood or psychotic changes, particularly during ziconotide titration. Reduce or stop ziconotide if cognitive or psychiatric deterioration occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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