Drug interactions
Asenapine transdermal + Fluconazole
Severity: Moderate
Asenapine transdermal and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine and fluconazole each have QT-prolonging potential. Combined use may increase the risk of ventricular arrhythmias including torsades de pointes, especially in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Asenapine transdermal and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Check a baseline ECG and keep potassium and magnesium normal. Monitor the QTc during the combination and stop or change therapy if it lengthens markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Fluconazole?
MediHelp rates the interaction as moderate. Asenapine transdermal and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine and fluconazole each have QT-prolonging potential. Combined use may increase the risk of ventricular arrhythmias including torsades de pointes, especially in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Asenapine transdermal and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and keep potassium and magnesium normal. Monitor the QTc during the combination and stop or change therapy if it lengthens markedly.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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