Drug interactions
Asenapine transdermal + Goserelin
Severity: Moderate
Asenapine transdermal and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval and goserelin, through androgen suppression, may add to this effect. The combination could increase the chance of torsades de pointes in susceptible patients.
What this interaction means in plain words
Asenapine transdermal and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the ECG periodically, and choose an antipsychotic with less QT effect if other risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Frequently asked questions
Can I take Asenapine transdermal with Goserelin?
MediHelp rates the interaction as moderate. Asenapine transdermal and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval and goserelin, through androgen suppression, may add to this effect. The combination could increase the chance of torsades de pointes in susceptible patients.
How serious is the interaction between Asenapine transdermal and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the ECG periodically, and choose an antipsychotic with less QT effect if other risk factors exist.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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