Drug interactions
Asenapine transdermal + Sevoflurane
Severity: Moderate
Asenapine transdermal and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval and cause orthostatic hypotension and sedation. Sevoflurane adds to QT prolongation and to hypotensive and sedative effects.
What this interaction means in plain words
Asenapine transdermal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation along with additive hypotension and CNS depression.
What to do
Obtain a baseline ECG and correct electrolytes before surgery. Monitor the ECG and blood pressure during anesthesia and continue antipsychotic therapy per the perioperative plan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Asenapine transdermal with Sevoflurane?
MediHelp rates the interaction as moderate. Asenapine transdermal and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval and cause orthostatic hypotension and sedation. Sevoflurane adds to QT prolongation and to hypotensive and sedative effects.
How serious is the interaction between Asenapine transdermal and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before surgery. Monitor the ECG and blood pressure during anesthesia and continue antipsychotic therapy per the perioperative plan.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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