Drug interactions
Asenapine transdermal + Tramadol
Severity: Moderate
Asenapine transdermal and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a sedating antipsychotic and tramadol is an opioid, so together they can increase drowsiness and respiratory depression. Tramadol also lowers the seizure threshold and carries serotonergic risk.
What this interaction means in plain words
Asenapine transdermal and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; antipsychotics may also further lower the seizure threshold.
What to do
Monitor for sedation, orthostasis and seizures, and use the lowest effective tramadol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Tramadol?
MediHelp rates the interaction as moderate. Asenapine transdermal and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is a sedating antipsychotic and tramadol is an opioid, so together they can increase drowsiness and respiratory depression. Tramadol also lowers the seizure threshold and carries serotonergic risk.
How serious is the interaction between Asenapine transdermal and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and seizures, and use the lowest effective tramadol dose.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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