Drug interactions
Acetylsalicylic acid + Duloxetine
Severity: Moderate
Acetylsalicylic acid and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine, like other serotonergic antidepressants, increases bleeding risk, especially upper GI bleeding, when combined with aspirin. The risk is higher in older patients or those with prior ulcers.
What this interaction means in plain words
Acetylsalicylic acid and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Duloxetine belongs to Central Nervous System.
Why it happens
Inhibition of platelet serotonin uptake impairs aggregation, adding to aspirin's antiplatelet and gastric effects.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and counsel on bleeding symptoms. Monitor hemoglobin if bleeding is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Duloxetine?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine, like other serotonergic antidepressants, increases bleeding risk, especially upper GI bleeding, when combined with aspirin. The risk is higher in older patients or those with prior ulcers.
How serious is the interaction between Acetylsalicylic acid and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and counsel on bleeding symptoms. Monitor hemoglobin if bleeding is suspected.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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