Drug interactions
Aspirin + Hydrochlorothiazide-irbesartan
Severity: Moderate
Aspirin and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses aspirin can blunt the antihypertensive effect of irbesartan and hydrochlorothiazide and add to the risk of renal function decline. Low-dose cardioprotective aspirin is generally not clinically significant.
What this interaction means in plain words
Aspirin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal perfusion and sodium excretion, opposing ARB and diuretic effects.
What to do
For high-dose aspirin, monitor blood pressure, creatinine and potassium and maintain hydration. Low-dose aspirin usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Aspirin with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Aspirin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses aspirin can blunt the antihypertensive effect of irbesartan and hydrochlorothiazide and add to the risk of renal function decline. Low-dose cardioprotective aspirin is generally not clinically significant.
How serious is the interaction between Aspirin and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For high-dose aspirin, monitor blood pressure, creatinine and potassium and maintain hydration. Low-dose aspirin usually needs no change.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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