Drug interactions
Aspirin + Latanoprost
Severity: Minor
Aspirin and Latanoprost: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Studies of ophthalmic prostaglandin analogues combined with NSAIDs have given inconsistent results on intraocular pressure. NSAIDs inhibit prostaglandin synthesis, which could blunt the pressure-lowering effect of latanoprost, although this is not consistently shown.
What this interaction means in plain words
Aspirin and Latanoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic interference of NSAID prostaglandin synthesis inhibition with prostaglandin analogue activity; the mechanism is not established.
What to do
No empirical adjustment is needed. Check intraocular pressure at routine follow-up if an NSAID is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Latanoprost
- Bimatoprost + Latanoprost Moderate
- Latanoprost + Latanoprostene bunod Moderate
- Latanoprost + Tafluprost Moderate
- Latanoprost + Travoprost Moderate
- Aspirin rectal + Latanoprost Minor
- Bromfenac + Latanoprost Minor
Frequently asked questions
Can I take Aspirin with Latanoprost?
MediHelp rates the interaction as minor. Aspirin and Latanoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Studies of ophthalmic prostaglandin analogues combined with NSAIDs have given inconsistent results on intraocular pressure. NSAIDs inhibit prostaglandin synthesis, which could blunt the pressure-lowering effect of latanoprost, although this is not consistently shown.
How serious is the interaction between Aspirin and Latanoprost?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed. Check intraocular pressure at routine follow-up if an NSAID is started or stopped.
What other medicines interact with Latanoprost?
MediHelp also lists interactions of Latanoprost with, for example, Bimatoprost, Latanoprostene bunod, Tafluprost. The full list is on the Latanoprost page.
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