Drug interactions
Acetylsalicylic acid + Metolazone
Severity: Moderate
Acetylsalicylic acid and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose aspirin can reduce the diuretic and antihypertensive effectiveness of metolazone and may impair renal function in volume-depleted patients. Low-dose aspirin has little effect.
What this interaction means in plain words
Acetylsalicylic acid and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, causing sodium and water retention and reduced renal blood flow, antagonising diuretic action.
What to do
Monitor blood pressure, fluid status, and renal function when using analgesic-dose aspirin with metolazone. Prefer low-dose aspirin or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Metolazone
Frequently asked questions
Can I take Acetylsalicylic acid with Metolazone?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin can reduce the diuretic and antihypertensive effectiveness of metolazone and may impair renal function in volume-depleted patients. Low-dose aspirin has little effect.
How serious is the interaction between Acetylsalicylic acid and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, and renal function when using analgesic-dose aspirin with metolazone. Prefer low-dose aspirin or an alternative analgesic.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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