Drug interactions
Azilsartan-chlorthalidone + Metolazone
Severity: Major
Azilsartan-chlorthalidone and Metolazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining chlorthalidone with metolazone produces strong sequential or additive diuresis with a high risk of hypokalemia, hyponatremia, hypomagnesemia, dehydration and hypotension.
What this interaction means in plain words
Azilsartan-chlorthalidone and Metolazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Additive inhibition of distal tubule sodium-chloride reabsorption with increased urinary potassium and sodium losses.
What to do
Avoid using both unless deliberately intended for resistant edema. If used, monitor electrolytes, renal function, volume status and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Metolazone
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Metolazone?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Metolazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining chlorthalidone with metolazone produces strong sequential or additive diuresis with a high risk of hypokalemia, hyponatremia, hypomagnesemia, dehydration and hypotension.
How serious is the interaction between Azilsartan-chlorthalidone and Metolazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both unless deliberately intended for resistant edema. If used, monitor electrolytes, renal function, volume status and blood pressure closely.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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