Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Metolazone
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Metolazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone combined with hydrochlorothiazide produces additive diuresis through sequential or overlapping thiazide-type action, causing marked sodium, potassium and magnesium loss, volume depletion, hypotension and renal impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Metolazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Duplicate thiazide-type inhibition of the distal tubule sodium-chloride cotransporter produces additive natriuresis and electrolyte loss.
What to do
Avoid combining two thiazide-type diuretics unless deliberately used for resistant edema under supervision. If used, monitor electrolytes, creatinine, weight and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Metolazone
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Metolazone?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Metolazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metolazone combined with hydrochlorothiazide produces additive diuresis through sequential or overlapping thiazide-type action, causing marked sodium, potassium and magnesium loss, volume depletion, hypotension and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Metolazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics unless deliberately used for resistant edema under supervision. If used, monitor electrolytes, creatinine, weight and blood pressure closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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