Drug interactions
Aspirin / citric acid / sodium bicarbonate + Digoxin
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent analgesic has a substantial sodium and alkali load and contains aspirin; no direct meaningful effect on digoxin kinetics is established. Sodium load may matter in heart failure.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established direct interaction; antacid components could theoretically alter absorption slightly.
What to do
Avoid routine use in heart failure because of sodium content; separate from digoxin by about 2 hours if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Digoxin?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This effervescent analgesic has a substantial sodium and alkali load and contains aspirin; no direct meaningful effect on digoxin kinetics is established. Sodium load may matter in heart failure.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine use in heart failure because of sodium content; separate from digoxin by about 2 hours if used regularly.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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