Drug interactions
Aspirin / citric acid / sodium bicarbonate + Hydrochlorothiazide-irbesartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic-dose aspirin can blunt the antihypertensive effect of irbesartan and, together with a thiazide and an ARB, raises the risk of acute kidney injury, especially in older or volume-depleted patients. Potassium may also rise because of reduced renal function and prostaglandin inhibition.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins by aspirin reduces renal perfusion and sodium excretion, which opposes ARB/diuretic effects and adds to hemodynamic renal stress.
What to do
Monitor blood pressure, serum creatinine and potassium when aspirin at analgesic doses is used regularly, and ensure adequate hydration. Low-dose aspirin for cardioprotection generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic-dose aspirin can blunt the antihypertensive effect of irbesartan and, together with a thiazide and an ARB, raises the risk of acute kidney injury, especially in older or volume-depleted patients. Potassium may also rise because of reduced renal function and prostaglandin inhibition.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when aspirin at analgesic doses is used regularly, and ensure adequate hydration. Low-dose aspirin for cardioprotection generally needs no change.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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