Drug reference
ticlopidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Platelets)
Mechanism of action
Platelet aggregation inhibitor; reversibly interacts with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation
Common side effects
- Rash
- Dyspepsia
- Nausea
- Elevated alkaline phosphatase
- Diarrhea
Boxed warnings
- May cause life-threatening hematologic events, including neutropenia, agranulocytosis, thrombocytopenia purpura, and aplastic anemia
Contraindications
- Neutropenia, thrombocytopenia, hemostatic disorder or active bleeding (GI bleed, ICH), severe hepatic impairment, history of either thrombotic thrombocytopenic purpura (TTP) or aplastic anemia Current use of other anticoagulant drugs
Known interactions (5)
- dalteparin + ticlopidine Major
- enoxaparin + ticlopidine Major
- fondaparinux + ticlopidine Major
- heparin + ticlopidine Major
- argatroban + ticlopidine Moderate
Related conditions
Frequently asked questions
What drug class is ticlopidine?
ticlopidine belongs to: Cardiovascular.
How does ticlopidine work?
Platelet aggregation inhibitor; reversibly interacts with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation
What are the common side effects of ticlopidine?
Rash, Dyspepsia, Nausea, Elevated alkaline phosphatase, Diarrhea
Which drugs interact with ticlopidine?
dalteparin, enoxaparin, fondaparinux, heparin, argatroban
Full monographs, dosing and an interaction checker in the MediHelp app
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