Drug interactions
Aspirin rectal + Ticlopidine
Severity: Major
Aspirin rectal and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and, with ticlopidine, adds antiplatelet effect and bleeding risk.
What this interaction means in plain words
Aspirin rectal and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effect through COX-1 inhibition and P2Y12 blockade.
What to do
Use only when dual antiplatelet therapy is indicated, and monitor for bleeding and blood counts. Consider a gastroprotective agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
- Mavacamten + Ticlopidine Contraindicated
- Abrocitinib + Ticlopidine Major
- Acetylsalicylic acid + Ticlopidine Major
- Apixaban + Ticlopidine Major
- Aspirin / citric acid / sodium bicarbonate + Ticlopidine Major
- Aspirin + Ticlopidine Major
Frequently asked questions
Can I take Aspirin rectal with Ticlopidine?
MediHelp rates the interaction as major. Aspirin rectal and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rectal aspirin is absorbed systemically and, with ticlopidine, adds antiplatelet effect and bleeding risk.
How serious is the interaction between Aspirin rectal and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when dual antiplatelet therapy is indicated, and monitor for bleeding and blood counts. Consider a gastroprotective agent.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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