Drug interactions
Apixaban + Ticlopidine
Severity: Major
Apixaban and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine is a potent antiplatelet drug and adds to apixaban's bleeding risk. Ticlopidine also carries hematologic toxicity, further complicating bleeding assessment.
What this interaction means in plain words
Apixaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive effects of P2Y12 receptor blockade and factor Xa inhibition.
What to do
Avoid if possible; clopidogrel is generally preferred when an antiplatelet is needed. If combined, monitor for bleeding and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Apixaban with Ticlopidine?
MediHelp rates the interaction as major. Apixaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine is a potent antiplatelet drug and adds to apixaban's bleeding risk. Ticlopidine also carries hematologic toxicity, further complicating bleeding assessment.
How serious is the interaction between Apixaban and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; clopidogrel is generally preferred when an antiplatelet is needed. If combined, monitor for bleeding and blood counts.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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