Drug interactions
Aspirin rectal + Digoxin
Severity: Minor
Aspirin rectal and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is systemically absorbed but at usual doses has no meaningful effect on digoxin or potassium. Clinically significant interaction is unlikely.
What this interaction means in plain words
Aspirin rectal and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism at usual doses; high-dose salicylate may slightly reduce renal function.
What to do
No routine action needed; check renal function and digoxin level if high doses are used chronically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Aspirin rectal with Digoxin?
MediHelp rates the interaction as minor. Aspirin rectal and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rectal aspirin is systemically absorbed but at usual doses has no meaningful effect on digoxin or potassium. Clinically significant interaction is unlikely.
How serious is the interaction between Aspirin rectal and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; check renal function and digoxin level if high doses are used chronically.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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