Drug interactions
Aspirin rectal + Duloxetine
Severity: Moderate
Aspirin rectal and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and inhibits platelet aggregation, and duloxetine impairs platelet serotonin uptake. Together they raise bleeding risk, including gastrointestinal bleeding. Rectal administration lowers direct gastric contact but does not remove the systemic effects.
What this interaction means in plain words
Aspirin rectal and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function through COX-1 inhibition and reduced platelet serotonin uptake.
What to do
Monitor for bleeding and bruising. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Duloxetine?
MediHelp rates the interaction as moderate. Aspirin rectal and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and inhibits platelet aggregation, and duloxetine impairs platelet serotonin uptake. Together they raise bleeding risk, including gastrointestinal bleeding. Rectal administration lowers direct gastric contact but does not remove the systemic effects.
How serious is the interaction between Aspirin rectal and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising. Consider gastroprotection in high-risk patients.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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