Drug interactions
Aspirin rectal + Hydrochlorothiazide-irbesartan
Severity: Moderate
Aspirin rectal and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is systemically absorbed, so analgesic doses can blunt the effect of irbesartan and hydrochlorothiazide and add to renal risk, particularly in volume-depleted or elderly patients.
What this interaction means in plain words
Aspirin rectal and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, antagonizing the antihypertensive effect.
What to do
With repeated or high-dose use, monitor blood pressure, creatinine and potassium and maintain hydration. Occasional low-dose use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Aspirin rectal with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is systemically absorbed, so analgesic doses can blunt the effect of irbesartan and hydrochlorothiazide and add to renal risk, particularly in volume-depleted or elderly patients.
How serious is the interaction between Aspirin rectal and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With repeated or high-dose use, monitor blood pressure, creatinine and potassium and maintain hydration. Occasional low-dose use usually needs no change.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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