Drug interactions
Aspirin rectal + Vortioxetine
Severity: Moderate
Aspirin rectal and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and inhibits platelets, while vortioxetine can impair platelet function through serotonin depletion. The combination increases bleeding risk, particularly gastrointestinal, although the risk is lower with low doses.
What this interaction means in plain words
Aspirin rectal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: platelet serotonin depletion plus cyclooxygenase inhibition.
What to do
Monitor for signs of bleeding and consider gastroprotection in high-risk patients. Use the lowest effective aspirin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Aspirin rectal with Vortioxetine?
MediHelp rates the interaction as moderate. Aspirin rectal and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and inhibits platelets, while vortioxetine can impair platelet function through serotonin depletion. The combination increases bleeding risk, particularly gastrointestinal, although the risk is lower with low doses.
How serious is the interaction between Aspirin rectal and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection in high-risk patients. Use the lowest effective aspirin dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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